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Assassins Creed II Walkthrough The Messenger's Burden

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You need to run to a way point that is outside of the city.

Run through the North Gate.

Well anyways sprint directly to the waypoint. You should make it with several seconds to spare.

You will be attacked by several villagers. You can take them out however you want.

I decided to be a nice guy and switched to hand to hand. That way I could just knock them out instead of killing them.

When they are all disabled The Messenger's Burden will be Synched.