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Assassins Creed: Brotherhood Walkthrough Sequence 2: part 3

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Run towards the wall and climb over it.

Climb ontop of the house and move over the horizontal beams until you reach the target.

Equip your hidden blade, highlight the target and press the attack button to air assassinate him (the air assassination is not mandatory but it is needed for 100% synchronization and it's easier).

Equip your sword again as soon as the cutscene is over beacaus you will be attacked by the guards.

To finish the mission either kill the guards or run away and become anonymous.